Thus, mild effects of both the nutrient-sensitive peptides the GLP-1RA exendin-4 and irisin on mitochondrial respiration observed in our study may be a part of an adaptive response, preventing mitochondrial damage and subsequent proinflammatory and dysfunctional adipocytes
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Indeed, a post mortem study of brains demonstrated more neuropathology in non-hypertensives, than in hypertensives on ARBs (Hoffman et al., 2009)
Thus, in analogy to the anti-ferroptotic function of DHODH 19 , we proposed the following working model: LDHB reduces ubiquinone to ubiquinol in the inner mitochondrial membrane, thereby suppressing mitochondria-associated ferroptosis (Fig